Hi, long story short, yes it is. However, you may not find it as simple as just just injecting a mystery liquid and collecting nice clear fractions of separate compounds. Big questions would be, what solvent to use? what column to use? How do you discern what fractions are "known" compounds and what are "unknown" even if you do get nice fractions?
I'd maybe start with a TLC plate, unless you have a MALDI-MS or another LCMS then perhaps you can just start firing away and let the database do the hard work.
Even after HPLC, you'd still have to run IR, NMR, MS to then figure out what it is you even got, and if it's new, but, that sounds like a fun challenge to me!
Here is a quick return on a google search for screening for new compounds from plant extracts.
Perhaps someone can give you a better, more detailed explanation of the steps to take, good luck, and is this for school or for a personal project?
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